ABSTRACT
BACKGROUND: Molluscum contagiosum is often a difficult problem for dermatologists to treat. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The use of cimetidine in the treatment of molluscum contagiosum has been reported previously using a dose of 40 mg/kg/day, and has the advantage of being painless and easy to administer, especially for recurrent, extensive, facial and eyelid lesions. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for molluscum contagiosum. METHODS: Twenty patients with molluscum contagiosum were treated using high dose cimetidine therapy (14 females, 6 males; age range 2~16 years). RESULTS: Of the 20 patients who completed the study, 12 patients (60%) showed complete remission, 3 patients (15%) showed partial remission and 5 patients (25%) showed no response. Five out of 8 patients with atopic dermatitis showed complete remission and one showed partial remission. Of the 12 patients without atopic dermatitis, 7 showed complete remission and 2 showed partial remission. CONCLUSION: High dose cimetidine therapy is an effective treatment modality for molluscum contagiosum, and has no severe adverse effects.
Subject(s)
Female , Humans , Male , Cimetidine , Dermatitis, Atopic , Eyelids , Molluscum Contagiosum , Peptic Ulcer , Receptors, HistamineABSTRACT
Subungual exostosis is a benign, acquired tumor of cartilaginous bone which occurs beneath the nail of the distal phalanx, and can often lead to displacement and deformity of the overlying nail. Complete surgical excision is a curative treatment for subungual exostosis. Since there have been no case reports of complete surgical removal of subungual exostosis in the Korean dermatologic literature, we report four cases of subungual exostosis that were successfully treated through complete excision or excision in combination with additional curettage.
Subject(s)
Congenital Abnormalities , Curettage , ExostosesABSTRACT
Syringoid eccrine carcinoma is a rare adnexal tumor of eccrine origin, and has metastatic potential and high recurrence rate following conventional surgical excision. Mohs micrographic surgery has been commonly used for various malignant skin cancers to minimize the defect after surgery, and to decrease the recurrence rate. We present a case of syringoid eccrine carcinoma successfully treated by Mohs micrographic surgery.
Subject(s)
Mohs Surgery , Recurrence , Skin NeoplasmsABSTRACT
BACKGROUND: It is often a difficult problem for dermatologists to treat verruca plana. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The successful use of cimetidine in the treatment of viral warts has been reported previously using doses of 40mg/kg/day and has the advantage of being painless and easy to administer. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for verruca plana. METHODS: Thirty-six patients with verruca plana were treated with high dose cimetidine therapy (22 females, 14 males; age range 7-56 years). RESULTS: Of the 36 patients who completed the study, 15 patients (41.7%) showed complete remission. 8 patients (22.2%) showed partial remission. There was no significant differences among the complete remission, the partial remission and the no response groups. There were a few adverse effects including transient liver enzyme elevation and gynecomastia which were normalized after the cimetidine was discontinued. CONCLUSION: High dose cimetidine therapy is an effective treatment modality for verruca plana without severe adverse effects.
Subject(s)
Female , Humans , Male , Cimetidine , Gynecomastia , Liver , Peptic Ulcer , Receptors, Histamine , WartsABSTRACT
BACKGROUND: Although surgical excision is the standard method for the treatment of venous malformations, this procedure often leads to massive bleeding and cosmetic problems. Sclerotherapy for venous malformations has recently been reported, whereas sclerotherapy for varicose veins, leg telangiectasias and hemorrhoids has well been established. PBJECTIVE: To assess the usefulness of sclerotherapy for venous malformations. METHOD: Fourteen patients who had venous malformation were treated with sclerotherapy using sodium tetradecyl sulfate (Thromboject(R), Omega Laboratories, Ltd., Montreal, Canada). Clinical efficacy was evaluated by physical examination and comparison of photographs. RESULTS: In patients with venous malformations, 71.4% of the eases showed moderate to marked improvement. Side effects were noted in 6 patients, however, they were trivial and transient and no treatment was needed. CONCLUSION: Sclerotherapy can be recommended as an effective method for the treatment of venous malformations. It has milder and fewer side effects than other treatment modalities, and it also yields superior cosmetic results.
Subject(s)
Humans , Hemorrhage , Hemorrhoids , Leg , Physical Examination , Sclerotherapy , Sodium Tetradecyl Sulfate , Telangiectasis , Varicose VeinsABSTRACT
We report a case of cutaneous cryptococcosis resembling verrucous granuloma on the lower lip in a 18-year-old female. She presented with a 3x1.5 cm sized painful verrucous granuloma with white, yellowish crust on the lower lip for 1 year. She had gotten many shunt operations for unexplained hydrocephalus. Histopathological examination showed numerous encapsulated round spores, epithelioid cells and giant cells in the dermis. A tissue culture on Sabouraud's dextrose agar without cycloheximide showed whitish creamy colonies. The organism was identified as Cryptococcus neoformans. The lesion disappeared with the treatment of oral itraconazole (100 mg/day) for 12 weeks.
Subject(s)
Adolescent , Female , Humans , Agar , Cryptococcosis , Cryptococcus neoformans , Cycloheximide , Dermis , Epithelioid Cells , Giant Cells , Glucose , Granuloma , Hydrocephalus , Itraconazole , Lip , SporesABSTRACT
We report a case of multiple osteoma cutis of the face in a 51-year-old female. She presented with 1-2mm sized skin colored multiple firm papules involving both cheeks for 2 years. She did not have any family history. Topical isotretinoin was prescribed for 6 months without any effects. Skin biopsy was done. Biopsy specimen of a skin colored papule on the right cheek showed numerous osteocytes and osteoblasts in the bony tissue. Other papules are treated by punch biopsy.